Extended-Release Melatonin; The Benefits Of Having A Prolonged-Release Action

It has always been a burden for most people when they continuously take medications on a regular interval. The problem is not usually with the medication but the timing ascribed to each drug. Some medicines are to be taken before a meal, while some are after a meal. It is not unusual that prescribers would advise that you take some between meals. For any medication to show maximum efficacy, it has to be taken as prescribed. The timing for each drug is another research that pharmacists have done to ensure those medications’ benefits optimal. Different types of formulation have been channeled towards the interval that you need to take drugs in this light.

One of the benefits that extended-release products have conferred on humans is compliance, which is a significant breakthrough in the drug delivery system. Melatonin has also been formulated as an extended-release tablet for patients or individuals that have issues adhering to an interval dosage of Melatonin. Melatonin would not do more than calming you and ensure that you feel the effect when night falls. The usual timing for the drug in the human system is five hours, and you might need to note this fact as we might have to refer to it later on. It is not true that only people who have specific health challenges require melatonin supplementation. Still, several students who read overnight might have their circadian rhythm disturbed for a long time. 

How does Melatonin operate?

It is essential to know how Melatonin works to understand the importance of the extended or prolonged Melatonin release. The longer a drug or supplement stays in the human system, the longer it renders its activity. Melatonin is produced by a gland known as the pineal gland found within the brain or, more accurately, in the middle of your brain. It is under the control of some neurons referred to as the suprachiasmatic nucleus, alternatively SCN. The neurons are in charge of signalling when it is time to produce Melatonin. During the day, the retina in the human eye signals the suprachiasmatic nucleus to stop the production of Melatonin, and at night the full activity of the SCN is seen as the production of Melatonin rises progressively.

Melatonin rises and quickly attains the peak level in less than an hour; the same happens when you take a melatonin supplement. You start to feel sleepy after the sudden rise. However, melatonin supplements might affect individuals differently. Some would feel the melatonin supplement’s effect in a short while, but it might take a bit for others. Most melatonin supplements you would find in health nutrition stores and pharmacies are rapid or immediate-release melatonin supplements. They do not take time to reach the peak level in the human system. On the other hand, the extended-release formulation, which is also referred to as prolong release, takes time to reach the peak level. 

It is not out of the blue when we use the world extended-release for a product that takes time to reach the peak level. This is because the particular product would stay longer in the body than the immediate-release formulation, and the efficacy would be accordingly. You would want to consider the extended-release Melatonin because it is usually a better product to simulate the effect of the natural Melatonin produced in the human body. You would like to go for a product that works the same way as the biological agent. There are several other names aside from the prolonged-release that has been used to refer to the extended-release melatonin supplement. Other synonyms are slow-release Melatonin, controlled-release Melatonin, and continuous release melatonin. All these names are focused on the delayed-release pattern of the formulation. However, the extended-release can be fantastic, but you need to rely on your physician’s advice before making your decision.

For most patients or individuals who have been prescribed the melatonin supplement, the supplement must be taken at a specific and regular time. Most prescribers would advise that melatonin supplements be taken 30 minutes before bedtime, while for others, the specified time is 60 minutes. It is all about the onset of action of Melatonin, and another factor that determines this timing is an individual’s absorption rates. It would not be fair when we talk about extended-release melatonin supplements without the time it takes for Melatonin itself to eliminate half of the supplement. The half-life of Melatonin is between 45-60 minutes, and the supplement takes 5 hours or lesser to remain active in the body.

It might take a different time for people taking an extended-release form of melatonin supplement, and it is not illogical when the extended-release takes longer than the regular or immediate-release Melatonin. However, some factors also affect the time it takes for Melatonin to be entirely excreted from the body, and they include caffeine intake, an individual’s health status, and body composition. You have to consider talking to your physician if you fall under the unique population such as pregnant women, the elderly, and individuals with autoimmune diseases, among others. When taking the extended-release Melatonin, you have to ensure that the appropriate dosage is taken because a specific dosage of an extended-release would not be equal to an immediate release dosage.